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La maggior parte dei pazienti in cui sono stati riportati questi eventi presentava fattori di rischio cardiovascolare preesistenti. Tuttavia, non è possibile determinare in maniera definitiva se tali eventi siano direttamente correlati a questi fattori di rischio, a tadalafil, all’attività sessuale o alla combinazione di questi od altri fattori.
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Il tadalafil può inibire debolmente anche la fosfodiesterasi di tipo six (PDE6; seven-hundred volte meno potente sulla PDE6 rispetto alla PDE5) che è un enzima coinvolto nella traduzione del segnale dei fotorecettori e quindi si possono osservare disturbi visivi occur la modifica della percezione dei colori. Si po' avere anche ipoacusia monolaterale.
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When sildenafil increases some markers of illness in individuals with pulmonary arterial hypertension, it doesn't seem to have an affect on the risk of Demise or critical Unintended effects.[twenty]
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